This is what successful

ADHD management

could look like.

Vyvanse: Now approved for adults with ADHD.

Fran's ADHD symptoms weren't

controlled during her day. She had trouble

focusing and finishing her work.

In a clinical study of adults w ith ADHD,

once daily Vyvanse significantly im proved

symptoms of inattention (e.g. lack of focus),

hyperactivity, and impulsivity within one week.

Ask your doctor about Vyvanse.

1-866-630-1283, www.vyvanse.com

FOR ADULTS WITH ADHD

.».Vyvanse”©

IMPORTANT SAFETY INFORMATION

Vyvanse is indicated for the treatment of ADHD. Efficacy based on two controlled

trials in children aged 6 to 12 and one controlled trial in adults.

Tell the doctor about any heart conditions, including structural abnor-

malities, that you, your child, or a family member, may have.

Inform the

doctor

immediately

if you or your child develops symptoms that suggest heart

problems, such as chest pain or fainting.

Vyvanse should not be taken if you or your child has advanced disease of the

blood vessels (arteriosclerosis); symptomatic heart disease; moderate to severe

high blood pressure; overactive thyroid gland (hyperthyroidism); known allergy

or unusual reactions to drugs called sympathom imetic am ines (for example,

pseudoephedrine); seizures; glaucoma; a history of problems with alcohol or

drugs; agitated states; taken a m onoam ine oxidase inhibitor (MAOI) within the

last 14 days.

Tell the doctor

before

taking Vyvanse if you or your child is being treated for

or has symptoms of depression (sadness, worthlessness, or hopelessness) or

bipolar disorder; has abnormal thought or visions, hears abnorm al sounds, or

has been diagnosed with psychosis; has had seizures or abnormal EEGs;has or has

had high blood pressure; exhibits aggressive behavior or hostility. Tell the doctor

immediately

if you or your child develops any of these conditions or symptoms

while taking Vyvanse.

Abuse of amphetamines may lead to dependence. Misuse of amphetamine

may cause sudden death and serious cardiovascular adverse events. These

events have also been reported rarely with amphetamine use.

Vyvanse was generally well tolerated in clinical studies.

The most common

side effects reported in studies of Vyvanse wer

e: children

-

decreased appetite,

difficulty falling asleep, stomachache, and irritability;

a d u lt-

decreased appetite,

difficulty falling asleep, and dry mouth.

Aggression, new abnorm al thoughts/behaviors, mania, growth suppression,

worsening of motion or verbal tics, and Tourette's syndrome have been associ-

ated with use of drugs of this type. Tell the doctor if you or your child has blurred

vision while taking Vyvanse.

(

Shire.

..your ADHD Support Company™

© 2008 Shire US Inc. LDX2998 08/08

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see Patient Brief Summary of Full Prescribing Information on the following page.